DBCO-C4-NHS Ester
| This amine reactive succinimidyl ester (NHS) functionalized cyclooctyne derivative (DBCO) provides easy attachment of the reactive moiety to primary containing compounds or biomolecules. DBCO reacts instantly with azides. DBCO is one of the most reactive cycloalkynes for strain-promoted alkyne azide cycloaddition (SPAAC) – a copper-free click chemistry reaction. DBCO reacts instantly with azides. The reaction rate is much higher than that of copper-catalyzed reaction, and reactions with many other cyclooctynes. Unlike some other cyclooctynes, DBCO does not react with tetrazines - this allows to carry out orthogonal conjugation of azides with DBCO, and trans-cyclooctenes with tetrazines. This amine-reactive NHS ester provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as protein, peptide, or small molecule amine. |
| Specifications | |
|---|---|
| CAS | 1353016-71-3 |
| Chemical Properties | |
| Molecular formula | C23H18N2O5 |
| Molecular weight | 402.41 |
| Purity | >97% |
